Response to hepatitis B vaccine in infants with mother-to-child HCV infection
Małgorzata Aniszewska, Barbara Kowalik-Mikołajewska, Maria Pokorska-Lis
Klinika Chorób Zakaźnych Wieku Dziecięcego,
Warszawski Uniwersytet Medyczny
Wojewódzki Szpital Zakaźny w Warszawie
Kierownik: dr hab. n med. M. Marczyńska
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- Fig. 1. Response to hepatitis B vaccine in infants infected and not infected with HCV
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- Table I. Characteristics of children infected with HCV vaccinated to hepatitis B
The aim of the study was to establish the vaccination-induced anti-HBs seroconversion in a group of children with mother-to-child HCV infection.
Material and methods: 105 infants born to HCV infected mothers were vaccinated against hepatitis B virus (10 µg/ml; 0, 1, 6 months). HCV infection (HCV-RNA RT-PCR, Abbot Laboratories, in serum positive infants detected twice in the first year of life) was confirmed in 18 (group A). 87 infants were HCV uninfected (group B). Anti-HBs titers (Ortho-EIA) were measured 1-6 months after the third dose of immunisation.
Results: Seroconversion to anti-HBs >10 mIU/ml was achieved in 93 (88.6%) infants: 13/18 (73%) in group A, 80/87 (92%) in group B. Anti-HBs <10 mIU/ml was observed in 12 (11.3%) children: 5 (27%) in group A, and 7 (8%) in group B (p=0.04).
Conclusion: Response to hepatitis B vaccine in infants infected with HCV was weaker than in nonvaccinated infants.
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